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woman portrait crying sad tears face emotion expression pain suffering anguish despair melancholy sorrow grief heartache misery unhappiness depression mental health illness disease disorder problem issue challenge struggle difficulty hardship burden weight pressure stress strain tension anxiety fear worry concern trouble distress agitation upset disturbed bothered irritated annoyed frustrated angry mad furious enraged livid irate incensed outraged appalled horrified shocked stunned dismayed discouraged disappointed let down betrayed abandoned neglected ignored shunned ostracized excluded isolated alone lonely forsaken deserted abandoned marooned stranded lost helpless hopeless despairing suicidal depressed unhappy miserable unlucky unfortunate cursed damned doomed condemned sentenced executed dead gone passed away deceased lost vanished disappeared missing never seen again